2481-26-7Relevant articles and documents
Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification
Fujishiro, Shinya,Dodo, Kosuke,Iwasa, Eriko,Teng, Yuou,Sohtome, Yoshihiro,Hamashima, Yoshitaka,Ito, Akihiro,Yoshida, Minoru,Sodeoka, Mikiko
, p. 733 - 736 (2013/03/13)
Chaetocin (1), a structurally complex epidithiodiketopiperazine (ETP) alkaloid produced by Chaetomium minutum, is a potent inhibitor of protein lysine methyltransferase G9a, which plays important roles in many biological processes. Here we present our syn
Practical one-pot double functionalizations of proline
Huy, Peter,Schmalz, Hans-Guenther
, p. 954 - 960 (2011/05/07)
Solubilization of proline as the triethylammonium salt allows N-protection (as the Boc, Cbz or Moc derivative) and subsequent esterification or amidation of the carboxy terminus to be performed in an efficient one-pot fashion. Based on this concept, highly practical protocols were developed to prepare a series of proline derivatives (including Pro-Ser dipetides, Weinreb amides and N-protected proline esters), which are important intermediates, for instance, for the synthesis of proline-derived peptides, chiral reagents and catalysts for asymmetric synthesis. Georg Thieme Verlag Stuttgart - New York.
Fluorous Coupling Reagents: Application of 2-Chloro-4,6- bis[(heptadecafluorononyl)oxy]-1,3,5-triazine in Peptide Synthesis
Markowicz, Marcin W.,Dembinski, Roman
, p. 80 - 86 (2007/10/03)
Benzyloxycarbonyl N-protected and C-terminus methyl ester protected amino acids react in THF in the presence of 4-methylmorpholine and fluorous condensation reagent, 2-chloro-4,6-bis[(heptadecafluorononyl)oxy[-1,3,5- triazine, to form di- and tripeptides