2481-26-7

Usage

Uses

Used in Pharmaceutical Research and Development:
L-Serine, 1-[(phenylmethoxy)carbonyl]-L-prolyl-, methyl ester is used as a building block for the synthesis of peptides and proteins, which are essential components of many pharmaceutical products. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Production of Bioactive Compounds:
This chemical compound is also used in the production of various bioactive compounds, which have the potential to be used in the development of new drugs and therapies. Its versatility and reactivity make it a valuable asset in the field of medicinal chemistry.
It is important to handle and store L-Serine, 1-[(phenylmethoxy)carbonyl]-L-prolyl-, methyl ester with care, following all necessary safety precautions to ensure the safety of researchers and the integrity of the compound.

Upstream product

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 57320-65-7 1-(p-chlorobenzenesulfonyloxy)-6-chloro-1,2,3-benzotriazole 
• 54769-27-6 1-benzenesulfonyloxy-6-chloro-1H-benzotriazole 
• 501-53-1 benzyl chloroformate 
• 147-85-3 L-proline 
• 2788-84-3 (S)-serine methyl ester 
• 3304-59-4 N-benzyloxycarbonyl-L-proline p-nitrophenyl ester 

Downstream Products

• 1269659-58-6 ((S)-4,5-dihydro-2-((S)-pyrrolidin-2-yl)oxazol-4-yl)diphenylmethanol 
• 1426960-29-3 C₂₃H₃₆N₂O₆Si 
• 73535-24-7 Z-Ser(Bzl)-Pro-Ser-NHNH₂ 
• 76863-48-4 (S)-2-((S)-1-Azidocarbonyl-2-hydroxy-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 155225-19-7 (2R,5S)-2-hydroxymethyl-1,4-diaza<4.3.0>bicyclononane 
• 2951-15-7 (S)-2-((S)-1-Hydrazinocarbonyl-2-hydroxy-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

Chaetocin (1), a structurally complex epidithiodiketopiperazine (ETP) alkaloid produced by Chaetomium minutum, is a potent inhibitor of protein lysine methyltransferase G9a, which plays important roles in many biological processes. Here we present our syn

Zinc-catalyzed amide cleavage and esterification of β- hydroxyethylamides

Snipping tool: Zn(OTf)2 is an efficient catalyst for selective cleavage of amides bearing a β-hydroxyethyl group on the nitrogen atom. The mechanism involves an N,O-acyl rearrangement and transesterification. This new catalytic system can be applied to sequence-specific peptide bond scission at the amine side of a serine residue. Tf=trifluoromethanesulfonyl. Copyright

Practical one-pot double functionalizations of proline

Solubilization of proline as the triethylammonium salt allows N-protection (as the Boc, Cbz or Moc derivative) and subsequent esterification or amidation of the carboxy terminus to be performed in an efficient one-pot fashion. Based on this concept, highly practical protocols were developed to prepare a series of proline derivatives (including Pro-Ser dipetides, Weinreb amides and N-protected proline esters), which are important intermediates, for instance, for the synthesis of proline-derived peptides, chiral reagents and catalysts for asymmetric synthesis. Georg Thieme Verlag Stuttgart - New York.

Fluorous Coupling Reagents: Application of 2-Chloro-4,6- bis[(heptadecafluorononyl)oxy]-1,3,5-triazine in Peptide Synthesis

Benzyloxycarbonyl N-protected and C-terminus methyl ester protected amino acids react in THF in the presence of 4-methylmorpholine and fluorous condensation reagent, 2-chloro-4,6-bis[(heptadecafluorononyl)oxy[-1,3,5- triazine, to form di- and tripeptides

Synthesis of (2R,5S)- and (2S,5S)-2-carboxy-1,4-diaza[4.3.0]bicyclononane as building blocks for the synthesis of new potential HIV protease inhibitors

A procedure for the preparation of optically active (2R,5S)- and (2S,5S)-2-carboxy-1,4-diaza-[4.3.0]bicyclononane is described. The method is based on the reduction of diketopiperazines obtained from cyclization of Pro-L-Ser or Pro-D-Ser and occurs withou

Chiral Ligands Containing Heteroatoms. 11. Optically Active 2-Hydroxymethyl Piperazines as Catalyst in the Enantioselective Addition of Diethylzinc to Benzaldehyde

Starting from enantiomerically pure serine, a series of (2R,5S) and (2S,5S)-2-hydroxymethyl-5-alkyl piperazines 1-5 were prepared in good yields without any racemization.The use of these compounds as chiral catalysts for the enantioselective addition of d

Amino Acids and Peptides. VI. Curtius Rearrangement of Acyl Amino Acid and Peptide Azides and Reactivity of the Isocyanates

Studies on the rate of Curtius rearrangement of acyl amino acid and peptide azides were carried out by means of IR (infrared) spectrophotometry at 25 deg.It was found that Z-Gly-N3 and Z-Pro-N3 were more stable than the other acyl amino acid azides.The re

Sulfonic acid esters

A novel process for the amidation or esterification which comprises reacting a compound having a carboxy group with a compound having an amino or imino group which can be acylated or with a compound having a hydroxy group in the presence of a sulfonic acid ester of the formula: wherein R1 is an organic group and R2 O-- is a residue of a strongly acidic N-hydroxy compound as a condensation agent, and a novel sulfonic acid ester useful as such a condensation agent and a process for the preparation thereof.