tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate

Base Information

• Chemical Name: tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate
• CAS No.: 1350910-19-8
• Molecular Formula: C₄₃H₅₆N₂O₄
• Molecular Weight: 664.929
• Mol file: 1350910-19-8.mol

Synonyms:tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate

Chemical Property of tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate

There total 1 articles about tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

tert-butyl (RS,E)-4-(N,N-dibenzylamino)-6-methylhept-2-enoate (1350909-99-7) + (R)-N-benzyl-1-phenylethylamine (38235-77-7) + (S)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amine (308273-67-8,680185-65-3) → tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate (1350910-38-1) + tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-6-methylheptanoate (1350910-19-8)

Guidance literature:

(R)-N-benzyl-1-phenylethylamine; (S)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tert-butyl (RS,E)-4-(N,N-dibenzylamino)-6-methylhept-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/ol203011u

upstream raw materials:

tert-butyl (RS,E)-4-(N,N-dibenzylamino)-6-methylhept-2-enoate

(R)-N-benzyl-1-phenylethylamine

(S)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amine