(1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

Base Information

Chemical Name:(1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol
CAS No.:952652-03-8
Molecular Formula:C₄₃H₄₂O₃Si
Molecular Weight:634.89
Hs Code.:

Synonyms:(1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

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Chemical Property of (1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

Chemical Property:

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Technology Process of (1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

There total 3 articles about (1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 952651-72-8
(+/-)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

: 108998-83-0
(S)-1,1,2-triphenyl-1,2-ethanediol

: 952652-02-7
(1'S,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

: 952652-03-8
(1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

Guidance literature:: (+/-)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane; With bromine; In dichloromethane; at -78 - 23 ℃;

(S)-1,1,2-triphenyl-1,2-ethanediol; With dmap; triethylamine; In dichloromethane; at 0 - 23 ℃; for 1h; Further stages.;
DOI:10.1021/ol071382h

Reference yield:

: 952651-71-7
(+/-)-(1-methoxy-2,2,2-triphenylethyl)(phenyl)dimethylsilane

: 952652-03-8
(1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Fe; Br₂ / 1,2-dichloro-ethane / 1.5 h / -10 °C

1.2: 98 percent / LiAlH₄ / 1,2-dichloro-ethane; diethyl ether / 3 h / 0 - 23 °C

2.1: Br₂ / CH₂Cl₂ / -78 - 23 °C

2.2: 38 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

With bromine; iron; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol071382h

Reference yield:

: 42365-04-8
triphenylacetaldehyde

: 952652-03-8
(1'R,2S)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsiloxy]-1,1,2-triphenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Li / tetrahydrofuran / 8 h / 0 °C

1.2: tetrahydrofuran / 0.5 h / -60 - -30 °C

1.3: 84 percent / tetrahydrofuran / 6 h / 23 °C

2.1: Fe; Br₂ / 1,2-dichloro-ethane / 1.5 h / -10 °C

2.2: 98 percent / LiAlH₄ / 1,2-dichloro-ethane; diethyl ether / 3 h / 0 - 23 °C

3.1: Br₂ / CH₂Cl₂ / -78 - 23 °C

3.2: 38 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

With bromine; lithium; iron; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol071382h