isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

Base Information

Chemical Name:isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine
CAS No.:1313733-00-4
Molecular Formula:C₂₆H₃₂F₃N₇O₂
Molecular Weight:531.581
Hs Code.:

isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

Synonyms:isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

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Chemical Property of isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

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Technology Process of isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

There total 5 articles about isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313732-59-0
7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

: 67-64-1
acetone

: 1313733-00-4
isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

Guidance literature:: 7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine; acetone; With sodium carbonate; at 20 ℃; for 4h;

With sodium cyanoborohydride; In acetone; at 20 ℃;

Reference yield:

: 66643-51-4
3,4-dichloro-5-<(2-hydroxyethyl)methylamino>-pyridazine

: 1313733-00-4
isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / Reflux

2.1: NCS / acetonitrile / 3 h / 50 °C

3.1: butan-1-ol / 1.5 h / 185 °C / Microwave irradiation

4.1: butan-1-ol / 180 - 185 °C / Microwave irradiation

5.1: sodium carbonate / 4 h / 20 °C

5.2: 20 °C

With potassium tert-butylate; sodium carbonate; In tetrahydrofuran; acetonitrile; butan-1-ol;

Reference yield:

: 66643-52-5
8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine

: 1313733-00-4
isopropyl-{7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-yl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NCS / acetonitrile / 3 h / 50 °C

2.1: butan-1-ol / 1.5 h / 185 °C / Microwave irradiation

3.1: butan-1-ol / 180 - 185 °C / Microwave irradiation

4.1: sodium carbonate / 4 h / 20 °C

4.2: 20 °C

With sodium carbonate; In acetonitrile; butan-1-ol;