N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide

Base Information

• Chemical Name: N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide
• CAS No.: 905562-63-2
• Molecular Formula: C₁₇H₁₇NO₂
• Molecular Weight: 267.327
• Mol file: 905562-63-2.mol

Synonyms:N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide

Chemical Property of N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide

There total 1 articles about N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diphenyloxazolidine-2,4-dione (17767-81-6) + allyl bromide (106-95-6) → N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide + N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide (905562-63-2)

Guidance literature:

3,5-diphenyloxazolidine-2,4-dione; allyl bromide; With potassium hydroxide; chiral tetraalkylammonium bromide; In water; at 0 ℃; for 7h;

In 1,4-dioxane; water; at 20 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1002/anie.200600470

Reference yield:

N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide (905562-63-2) → (2S)-2-hydroxy-2-phenyl-4-pentenoic acid (81037-04-9)

Guidance literature:

With potassium hydroxide; In ethylene glycol; at 150 ℃; for 18h;

DOI:10.1002/anie.200600470

Reference yield:

N-phenyl-2-hydroxy-2-phenyl-4-pentenylamide (905562-63-2) → methyl (S)-2-hydroxy-2-phenylpent-4-enoate

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethane-1,2-diol / 18 h / 150 °C

2: p-toluenesulfonic acid monohydrate / 4 h / Heating

With potassium hydroxide; toluene-4-sulfonic acid; In ethylene glycol;

DOI:10.1002/anie.200600470

upstream raw materials:

3,5-diphenyloxazolidine-2,4-dione

allyl bromide

Downstream raw materials:

(2S)-2-hydroxy-2-phenyl-4-pentenoic acid