4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

Base Information

Chemical Name:4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline
CAS No.:1354745-64-4
Molecular Formula:C₂₅H₁₉F₄NO₃
Molecular Weight:457.424
Hs Code.:

Synonyms:4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

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Chemical Property of 4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

Chemical Property:

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Technology Process of 4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

There total 8 articles about 4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1426337-32-7
4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,3,2-dioxaborolane

: 1599467-60-3
4-ethoxy-6-fluoro-3-iodo-2-methylquinoline

: 1354745-64-4
4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 18h; Molecular sieve;
DOI:10.1021/jm500147k

Reference yield:

: C₁₂H₁₄FNO₂

: 1354745-64-4
4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: dowtherm A / 0.33 h / 250 °C

2.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 8 h / 50 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C / Molecular sieve

With dowtherm A; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm500147k

Reference yield:

: 106-41-2
4-bromo-phenol

: 1354745-64-4
4-ethoxy-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate; N-ethyl-N,N-diisopropylamine; pyridine / dichloromethane / 12 h / 20 °C / Molecular sieve

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C / Molecular sieve

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500147k