2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Name:2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one
CAS No.:1300585-70-9
Molecular Formula:C₂₇H₁₅F₄N₅O₃
Molecular Weight:533.441
Hs Code.:

Synonyms:2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Property of 2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Technology Process of 2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

There total 10 articles about 2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1300585-69-6
2-((4-amino-3-(3,5-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

: 1300585-70-9
2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: With boron tribromide; In dichloromethane;

Reference yield:

: 331-25-9
(3-fluorophenyl)acetic acid

: 1300585-70-9
2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: sodium acetate / 12 h / Reflux

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h

5.1: boron tribromide / dichloromethane

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); sodium acetate; boron tribromide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 459-60-9
1-fluoro-4-methoxybenzene

: 1300585-70-9
2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: sodium acetate / 12 h / Reflux

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h

5.1: boron tribromide / dichloromethane

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); sodium acetate; boron tribromide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;