2,6-Difluorophenol

Base Information Edit

Chemical Name:2,6-Difluorophenol
CAS No.:28177-48-2
Molecular Formula:C6H4F2O
Molecular Weight:130.094
Hs Code.:29081000
European Community (EC) Number:248-884-9
DSSTox Substance ID:DTXSID00182456
Nikkaji Number:J236.192B
Wikidata:Q27460275
ChEMBL ID:CHEMBL1232721
Mol file:28177-48-2.mol

Synonyms:2,6-difluorophenol

Suppliers and Price of 2,6-Difluorophenol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,6-Difluorophenol
25g
$ 275.00

TCI Chemical
2,6-Difluorophenol >98.0%(GC)
25g
$ 296.00

TCI Chemical
2,6-Difluorophenol >98.0%(GC)
5g
$ 78.00

SynQuest Laboratories
2,6-Difluorophenol 98%
100 g
$ 195.00

SynQuest Laboratories
2,6-Difluorophenol 98%
5 g
$ 15.00

SynQuest Laboratories
2,6-Difluorophenol 98%
25 g
$ 55.00

Sigma-Aldrich
2,6-Difluorophenol 98%
5g
$ 54.00

Matrix Scientific
2,6-Difluorophenol 98%
100g
$ 263.00

Matrix Scientific
2,6-Difluorophenol 98%
25g
$ 74.00

Matrix Scientific
2,6-Difluorophenol 98%
5g
$ 18.00

Total 131 raw suppliers

Chemical Property of 2,6-Difluorophenol Edit

Chemical Property:

Appearance/Colour:white crystal
Vapor Pressure:2.11mmHg at 25°C
Melting Point:38-42 °C
Refractive Index:1.495
Boiling Point:157.7 °C at 760 mmHg
PKA:7.45±0.10(Predicted)
Flash Point:58 °C
PSA：20.23000
Density:1.351 g/cm³
LogP:1.67040
Storage Temp.:2-8°C
Solubility.:ethanol: soluble50mg/mL, clear, colorless to light yellow
Water Solubility.:Slightly soluble in water. Soluble in ethanol.
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:130.02302107
Heavy Atom Count:9
Complexity:87.1

Purity/Quality:

99% ^*data from raw suppliers

2,6-Difluorophenol ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xi,Xn
Hazard Codes:F,Xi,Xn
Statements: 11-36/37/38-20/21/22
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)F)O)F
Recent ClinicalTrials:Early Convalescent Plasma Therapy for High-risk Patients With COVID-19 in Primary Care (the CoV-Early Study)
Uses 2,6-Difluorophenol undergoes oxidative polymerization in the presence of the Fe-N,N?-bis(salicylidene)ethylenediamine (salen) complex (catalyst) and hydrogen peroxide (oxidizing agent) to give poly(2,6-difluoro-1,4-phenylene oxide). It is also used as pharmaceutical intermediates.

Technology Process of 2,6-Difluorophenol

There total 19 articles about 2,6-Difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 162101-25-9
2,6-difluorophenylboronic acid

: 28177-48-2
2,6-difluorophenol

Guidance literature:: With dihydrogen peroxide; In water; at 30 ℃; Green chemistry;
DOI:10.1016/j.tetlet.2019.06.018

Reference yield: 92.1%

: 121602-93-5,255875-61-7
3,4,5-trifluorobenzoic acid

: 28177-48-2
2,6-difluorophenol

Guidance literature:: With water; lithium carbonate; at 180 - 185 ℃; for 12h; Sealed tube;

Reference yield: 88.9%

: 5509-65-9
2,6-difluoroaniline

: 28177-48-2
2,6-difluorophenol

Guidance literature:: 2,6-difluoroaniline; With sulfuric acid; sodium nitrite; In water; at -5 - 0 ℃; for 2h; Green chemistry; Large scale;

With sulfuric acid; copper(II) sulfate; In water; Reagent/catalyst; Temperature; Reflux; Green chemistry; Large scale;