(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

Base Information

Chemical Name:(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate
CAS No.:1447673-31-5
Molecular Formula:C₁₂H₁₃N*C₁₅H₁₉NO₄
Molecular Weight:448.562
Hs Code.:

Synonyms:(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

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Chemical Property of (S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

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Technology Process of (S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

There total 17 articles about (S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: 1447673-31-5
(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

: cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid

Guidance literature:: In acetonitrile; for 15h;

Reference yield:

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: (3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: 1447673-31-5
(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

Guidance literature:: In acetonitrile; at 30 ℃; for 16h; Overall yield = 60.2 g;

Reference yield:

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: 1428243-25-7
(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

: 1447673-31-5
(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

Guidance literature:: (S)-1-(1-Naphthyl)ethylamine; cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid; In acetonitrile; at 35 - 65 ℃; for 8h; Inert atmosphere; Resolution of racemate; Large scale;

With hydrogenchloride; In tert-butyl methyl ether; water; Inert atmosphere; Resolution of racemate; Large scale;

(R)-1-(1-Naphthyl)ethylamine; In acetonitrile; at 10 - 65 ℃; for 8h; Inert atmosphere; Resolution of racemate; Large scale;
DOI:10.1021/acs.oprd.1c00287