(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

Base Information

Chemical Name:(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt
CAS No.:1428243-25-7
Molecular Formula:C₁₂H₁₃N*C₁₅H₁₉NO₄
Molecular Weight:448.562
Hs Code.:

Synonyms:(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

Suppliers and Price of (3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

Chemical Property:

Purity/Quality:: 99.0% ^*data from raw suppliers

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Useful:

Uses (E/Z)-9-Hydroxy-5,9-dimethyldec-4-enal acts as a reagent in the preparation of imidazopyrrolopyrazine derivatives and analogs for use as protein kinase modulators.

Technology Process of (3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

There total 16 articles about (3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: 1428243-70-2
(R)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

: 1428243-25-7
(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

Guidance literature:: In acetonitrile; for 15h;

Reference yield:

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: 1428243-25-7
(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

Guidance literature:: (S)-1-(1-Naphthyl)ethylamine; 1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid; In acetonitrile; at 30 ℃; for 16h;

(R)-1-(1-Naphthyl)ethylamine; In acetonitrile; at 30 ℃; for 16h;

Reference yield:

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid

: 1428243-25-7
(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

: 1447673-31-5
(S)-1-(naphthalen-1-yl)ethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylate

Guidance literature:: (S)-1-(1-Naphthyl)ethylamine; cis-1-(benzyloxycarbonyl)-4-ethylpyrrolidine-3-carboxylic acid; In acetonitrile; at 35 - 65 ℃; for 8h; Inert atmosphere; Resolution of racemate; Large scale;

With hydrogenchloride; In tert-butyl methyl ether; water; Inert atmosphere; Resolution of racemate; Large scale;

(R)-1-(1-Naphthyl)ethylamine; In acetonitrile; at 10 - 65 ℃; for 8h; Inert atmosphere; Resolution of racemate; Large scale;
DOI:10.1021/acs.oprd.1c00287