(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Base Information

Chemical Name:(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide
CAS No.:1260171-67-2
Molecular Formula:C₃₁H₃₉N₅O₆S
Molecular Weight:609.747
Hs Code.:

Synonyms:(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

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Chemical Property of (S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Chemical Property:

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Technology Process of (S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

There total 9 articles about (S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 477585-31-2
4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride salt

: (S)-N-allyloxy-3-amino-2-(4-isobutyrylpiperazin-1-yl)propionamide dihydrochloride

: 1260171-67-2
(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

: 4-chloromethyl-2-methylquinoline hydrochloride salt

: 1260171-67-2
(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; isopropyl alcohol / 23 h / 40 - 70 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 18 h / -10 - 20 °C

3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 477585-26-5
sodium 4-(2-methylquinolin-4-ylmethoxy)benzenesulfonate

: 1260171-67-2
(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 18 h / -10 - 20 °C

2: triethylamine / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;