(S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Base Information

Chemical Name:(S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide
CAS No.:1260171-61-6
Molecular Formula:C₂₈H₃₅N₅O₆S
Molecular Weight:569.682
Hs Code.:

Synonyms:(S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

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Chemical Property of (S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

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Technology Process of (S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

There total 10 articles about (S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1260171-67-2
(S)-N-allyloxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

: 1260171-61-6
(S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Guidance literature:: With potassium carbamate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; for 8h; Reflux;

Reference yield:

: 477585-31-2
4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride salt

: (S)-N-allyloxy-3-amino-2-(4-isobutyrylpiperazin-1-yl)propionamide dihydrochloride

: 1260171-61-6
(S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: potassium carbamate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 8 h / Reflux

With potassium carbamate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4-chloromethyl-2-methylquinoline hydrochloride salt

: 1260171-61-6
(S)-N-hydroxy-2-(4-isobutyrylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; isopropyl alcohol / 23 h / 40 - 70 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 18 h / -10 - 20 °C

3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol / 8 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; potassium carbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;