4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

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Chemical Name:4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one
CAS No.:1309652-58-1
Molecular Formula:C₃₁H₃₄N₆O₂
Molecular Weight:522.65
Hs Code.:

Synonyms:4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

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Chemical Property of 4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

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Technology Process of 4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

There total 10 articles about 4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309651-81-7
(R,S)-2-phenyl-7-{4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl}chroman

: 4-((cis-3-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclobutyl)methyl)-1-methylpiperazin-2-one

: 1309652-58-1
4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

Guidance literature:: With potassium phosphate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 1.66667h; Inert atmosphere;

Reference yield:

: 6665-86-7,66585-10-2
7-hydroxyflavone

: 1309652-58-1
4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 h / 20 °C / 760.05 Torr

2: dmap; 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1.67 h / 100 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; potassium phosphate; hydrogen; potassium acetate; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 4: Suzuki Coupling;

Reference yield:

: 6515-36-2,2545-13-3
7-hydroxy-2-phenyl-chroman-4-one

: 1309652-58-1
4-{3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Cooling with ice

2.1: triethylsilane / dichloromethane / 0.08 h

2.2: 0.5 h / 20 °C

3.1: dmap; 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1.67 h / 100 °C / Inert atmosphere

With 2,6-dimethylpyridine; triethylsilane; dmap; potassium phosphate; borane-THF; potassium acetate; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;