ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

Base Information

Chemical Name:ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate
CAS No.:1403880-63-6
Molecular Formula:C₂₀H₁₅ClF₂N₂O₄S
Molecular Weight:452.866
Hs Code.:

Synonyms:ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

Suppliers and Price of ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

There total 2 articles about ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 951122-37-5
2,6-difluoro-3-hydroxy-benzamide

: 1403884-00-3
ethyl 2-bromo-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

: 1403880-63-6
ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1403880-63-6
ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / 75 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;

Reference yield: 50.0%

: 1403880-63-6
ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

: 1403880-65-8
3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Guidance literature:: ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Cooling with ice;

With hydrogenchloride; water;