3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Base Information

Chemical Name:3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide
CAS No.:1403880-65-8
Molecular Formula:C₁₈H₁₃ClF₂N₂O₃S
Molecular Weight:410.829
Hs Code.:

Synonyms:3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Suppliers and Price of 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

There total 2 articles about 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1403880-63-6
ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate

: 1403880-65-8
3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Guidance literature:: ethyl 2-(3-carbamoyl-2,4-difluorophenoxy)-2-(4-(4-chlorophenyl)thiazol-2-yl)acetate; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Cooling with ice;

With hydrogenchloride; water;

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1403880-65-8
3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 2 h / 75 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: sodium tetrahydroborate / methanol / 0.5 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;