N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine
• CAS No.: 1032903-61-9
• Molecular Formula: C₂₄H₂₉BrN₄O₃S
• Molecular Weight: 533.489

Synonyms:N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Chemical Property of N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

There total 1 articles about N₂-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-isopropoxy-4-methyl-phenylamine (1035230-17-1) + 2-chloro-5-methyl-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (1032903-48-2) → N2-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (1032903-61-9)

Guidance literature:

With methanesulfonic acid; In isopropyl alcohol; at 140 ℃; for 0.5h; Irradiation;

Reference yield:

N2-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (1032903-61-9) + trimethylsilylacetylene (1066-54-2) → N2-(2-isopropoxy-4-methyl-5-trimethylsilanylethynyl-phenyl)-5-methyl-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (1035230-26-2)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; bis(benzonitrile)palladium(II) dichloride; In 1,4-dioxane; at 22 - 60 ℃; for 22h;

Reference yield:

4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine (864754-18-7) + N2-(5-bromo-2-isopropoxy-4-methyl-phenyl)-5-methyl-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (1032903-61-9) → N2-{2-isopropoxy-4-methyl-5-[1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-4-yl]-phenyl}-5-methyl-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (1032900-22-3)

Guidance literature:

With potassium phosphate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 0.333333h; Irradiation;

upstream raw materials:

5-bromo-2-isopropoxy-4-methyl-phenylamine

2-chloro-5-methyl-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine

Downstream raw materials:

N₂-(2-isopropoxy-4-methyl-5-trimethylsilanylethynyl-phenyl)-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

N₂-{2-isopropoxy-4-methyl-5-[1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-4-yl]-phenyl}-5-methyl-N₄-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

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