3',5'-bis-O-(tert-butyldimethylsilyl)-O⁶-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine

Base Information

• Chemical Name: 3',5'-bis-O-(tert-butyldimethylsilyl)-O⁶-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine
• CAS No.: 150884-25-6
• Molecular Formula: C₃₁H₅₁N₅O₆SSi₂
• Molecular Weight: 678.013

Synonyms:3',5'-bis-O-(tert-butyldimethylsilyl)-O⁶-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine

Chemical Property of 3',5'-bis-O-(tert-butyldimethylsilyl)-O⁶-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine

Chemical Property:

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Technology Process of 3',5'-bis-O-(tert-butyldimethylsilyl)-O⁶-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine

There total 3 articles about 3',5'-bis-O-(tert-butyldimethylsilyl)-O⁶-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-mesitylenesulphonyl chloride (773-64-8) + 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (51549-35-0) → 3',5'-bis-O-(tert-butyldimethylsilyl)-O6-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine (150884-25-6)

Guidance literature:

With dmap; triethylamine; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; Ambient temperature;

DOI:10.1021/jo00072a050

Reference yield:

2'-Deoxyguanosine (961-07-9) → 3',5'-bis-O-(tert-butyldimethylsilyl)-O6-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine (150884-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole

2: DMAP

With 1H-imidazole; dmap;

DOI:10.1081/NCN-200060312

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3',5'-bis-O-(tert-butyldimethylsilyl)-O6-[(2,4,6-trimethylphenyl)sulfonyl]-2'-deoxyguanosine (150884-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole

2: DMAP

With 1H-imidazole; dmap;

DOI:10.1081/NCN-200060312

upstream raw materials:

2-mesitylenesulphonyl chloride

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

2'-Deoxyguanosine

tert-butyldimethylsilyl chloride

Downstream raw materials:

O⁶-phenyl-3',5'-bis(O-tert-butyldimethylsilyl)-2'-deoxyguanosine

O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

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