(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Base Information

Chemical Name:(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one
CAS No.:850003-11-1
Molecular Formula:C₁₇H₁₈N₄O₂
Molecular Weight:310.356
Hs Code.:

Synonyms:(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

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Chemical Property of (7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

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Technology Process of (7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

There total 15 articles about (7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850003-10-0
(7R,7aR)-7-azido-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

: 850003-11-1
(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; at 50 - 70 ℃; for 48h;

Reference yield:

: 142-08-5
2-hydroxypyridin

: 850003-11-1
(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: potassium phosphate; copper(l) iodide; N,N-dimethylethylenediamine / toluene / Heating / reflux

2: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 2 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0.75 - 1 h / 0 °C

7: sodium azide / dimethyl sulfoxide / 24 h / 80 °C

8: triphenylphosphine / tetrahydrofuran; water / 48 h / 50 - 70 °C

With potassium phosphate; copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; N,N-dimethylethylenediamine; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;

Reference yield:

: 850003-05-3
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester

: 850003-11-1
(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

Guidance literature:: Multi-step reaction with 9 steps

1: lithium triethylborohydride / tetrahydrofuran / 3.67 h / -78 - 20 °C

2: Dess-Martin periodane / 2 - 4 h / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 1 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 2 h / 0 - 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

7: triethylamine / dichloromethane / 0.75 - 1 h / 0 °C

8: sodium azide / dimethyl sulfoxide / 24 h / 80 °C

9: triphenylphosphine / tetrahydrofuran; water / 48 h / 50 - 70 °C

With sodium azide; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; lithium triethylborohydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;