5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

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Chemical Name:5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide
CAS No.:850000-85-0
Molecular Formula:C₂₂H₁₉ClN₄O₃S
Molecular Weight:454.937
Hs Code.:

Synonyms:5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

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Chemical Property of 5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

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Technology Process of 5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

There total 4 articles about 5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 850003-11-1
(7R,7aR)-7-amino-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one

: 850000-85-0
5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 142-08-5
2-hydroxypyridin

: 850000-85-0
5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium phosphate; copper(l) iodide; N,N-dimethylethylenediamine / toluene / Heating / reflux

2: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 2 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0.75 - 1 h / 0 °C

7: sodium azide / dimethyl sulfoxide / 24 h / 80 °C

8: triphenylphosphine / tetrahydrofuran; water / 48 h / 50 - 70 °C

9: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With 4-methyl-morpholine; potassium phosphate; copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N,N-dimethylethylenediamine; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 4298-08-2
trans-3-hydroxy-L-proline

: 850000-85-0
5-chloro-thiophene-2-carboxylic acid {(7R,7aR)-3-oxo-2-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-7-yl}-amide

Guidance literature:: Multi-step reaction with 13 steps

1: hydrogenchloride / 6.17 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: 1H-imidazole / dichloromethane / 20 °C

4: lithium triethylborohydride / tetrahydrofuran / 3.67 h / -78 - 20 °C

5: Dess-Martin periodane / 2 - 4 h / 0 - 20 °C

6: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 1 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 2 h / 0 - 20 °C

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

10: triethylamine / dichloromethane / 0.75 - 1 h / 0 °C

11: sodium azide / dimethyl sulfoxide / 24 h / 80 °C

12: triphenylphosphine / tetrahydrofuran; water / 48 h / 50 - 70 °C

13: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; hydrogenchloride; sodium azide; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; lithium triethylborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;