(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

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Chemical Name:(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester
CAS No.:126771-48-0
Molecular Formula:C₄₁H₃₂Cl₂N₂O₇
Molecular Weight:735.62
Hs Code.:

Synonyms:(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

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Chemical Property of (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

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Technology Process of (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

There total 3 articles about (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 35737-15-6
Fmoc-Trp-OH

: 126771-40-2
2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate

: 126771-48-0
(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)99355-9

Reference yield:

: 940-64-7
2-(4-methylphenoxy)acetic acid

: 126771-48-0
(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / N-bromosuccinimide, 2,2'-azobisisobutyronitrile / CHCl₃ / Heating

2: 85 percent / dicyclohexylcarbodiimide / ethyl acetate / 0 °C

3: 80 percent / diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)99355-9

Reference yield:

: 126771-41-3
4-bromomethylphenoxyacetic acid

: 126771-48-0
(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / dicyclohexylcarbodiimide / ethyl acetate / 0 °C

2: 80 percent / diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)99355-9