3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

Base Information

Chemical Name:3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester
CAS No.:200481-69-2
Molecular Formula:C₂₉H₃₀N₂O₅
Molecular Weight:486.568
Hs Code.:

Synonyms:3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

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Chemical Property of 3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

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Technology Process of 3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

There total 6 articles about 3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (2Z,4E)-3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-penta-2,4-dienoic acid methyl ester

: 200481-69-2
3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; under 2327.2 Torr;
DOI:10.1021/jm970485a

Reference yield:

: 6136-68-1
3-acethylbenzonitrile

: 200481-69-2
3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / sodium methoxide / methanol / Ambient temperature

2: 58 percent / toluene / 100 °C

3: 84 percent / H₂ / 10percent Pd/C / ethyl acetate; tetrahydrofuran / 2327.2 Torr

With hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/jm970485a

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 200481-69-2
3-(3-Cyano-phenyl)-5-[4-(2,4-dimethoxy-benzylcarbamoyl)-phenyl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / dimethylformamide / 24 h / Ambient temperature

2: 52 percent / sodium methoxide / methanol / Ambient temperature

3: 58 percent / toluene / 100 °C

4: 84 percent / H₂ / 10percent Pd/C / ethyl acetate; tetrahydrofuran / 2327.2 Torr

With dmap; hydrogen; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm970485a