(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester
CAS No.:135632-14-3
Molecular Formula:C₄₂H₆₃N₅O₇S
Molecular Weight:782.058
Hs Code.:

(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

Synonyms:(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

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Chemical Property of (1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

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Technology Process of (1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

There total 11 articles about (1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

: 135632-56-3
N-(S-methyl-L-cysteinyl)-(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine

: 135632-29-0
(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

: 135632-14-3
(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1021/jm00071a009

Reference yield:

: 116129-80-7
(3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid

: 135632-14-3
(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

2: Et₃N / CH₂Cl₂ / 3 h / 0 °C

3: 96.8 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 760 Torr

4: 67.7 percent / HOBt*H₂O, N-ethylmorpholine, HBTU / acetonitrile / 2 h / Ambient temperature

With N-ethylmorpholine;; oxalyl dichloride; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00071a009

Reference yield:

: 136159-65-4,96930-27-7
(S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one

: 135632-14-3
(1-{(R)-3-[(R)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-methylsulfanyl-ethylcarbamoyl]-4-phenyl-butyryl}-piperidin-4-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) sodium hexamethyldisilylamide / 1.) THF, -65 deg C, 45 min, 2.) THF, -70 deg C, 3 h

2: 1.) n-butyllithium / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 3 h

3: 92.5 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

4: oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

5: Et₃N / CH₂Cl₂ / 3 h / 0 °C

6: 96.8 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 760 Torr

7: 67.7 percent / HOBt*H₂O, N-ethylmorpholine, HBTU / acetonitrile / 2 h / Ambient temperature

With N-ethylmorpholine;; n-butyllithium; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00071a009