7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Base Information

• Chemical Name: 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• CAS No.: 88369-18-0
• Molecular Formula: C₁₈H₁₅ClN₂O₃
• Molecular Weight: 343.774

Synonyms:7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Chemical Property of 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Chemical Property:

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Technology Process of 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one

There total 1 articles about 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid ethyl ester (5606-55-3,91547-33-0,91547-34-1) → 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H1>-1,3-dihydro-2H-1,4-benzodiazepin-2-one (88369-18-0)

Guidance literature:

With trifluoroacetic acid-d₁; water-d2; In tetrahydrofuran; for 24h; Heating;

DOI:10.1002/jhet.5570200534

Reference yield: 85.0%

7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H1>-1,3-dihydro-2H-1,4-benzodiazepin-2-one (88369-18-0) → 7-chloro-5-phenyl-3-hydroxymethyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepin-2-one (88369-19-1)

Guidance literature:

With sodium aluminum diethyl dihydride; In tetrahydrofuran; toluene; for 0.5h; Ambient temperature;

DOI:10.1002/jhet.5570200534

Reference yield:

7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H1>-1,3-dihydro-2H-1,4-benzodiazepin-2-one (88369-18-0) → 7-chloro-5-phenyl-3-methyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepine (88369-23-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / sodium diethyldihydroaluminate / toluene; tetrahydrofuran / 0.5 h / Ambient temperature

2: pyridine / 2 h / Ambient temperature

3: 76 percent / LiAlH₄ / tetrahydrofuran / 16 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sodium aluminum diethyl dihydride; In tetrahydrofuran; toluene;

DOI:10.1002/jhet.5570200534

upstream raw materials:

7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid ethyl ester

Downstream raw materials:

7-chloro-5-phenyl-3-hydroxymethyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepin-2-one

7-chloro-5-phenyl-3-methyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepine

7-chloro-5-phenyl-3-methyl-2,2,3,3'-tetradeuterio-1,3-dihydro-2H-1,4-benzodiazepine

C₂₃H₁₈⁽²⁾HClN₂O₄S

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