(2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Base Information

Chemical Name:(2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
CAS No.:188109-89-9
Molecular Formula:C₁₁H₁₉NO₄S
Molecular Weight:261.342
Hs Code.:

Synonyms:(2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Suppliers and Price of (2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(4S)-1-Boc-4-methylthiol-L-proline 95+%
1g
$ 1516.00

Total 5 raw suppliers

Chemical Property of (2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(4S)-1-Boc-4-methylthiol-L-proline 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

There total 13 articles about (2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 77-78-1
dimethyl sulfate

: 211299-16-0
1-(tert-butyl) 2-methyl 4-(acetylthio)pyrrolidine-1,2-dicarboxylate

: 188109-89-9
(2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 3.5h;
DOI:10.1016/j.bmc.2005.11.001

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 188109-89-9
(2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 3.7 g / Na₂CO₃ / dioxane; H₂O / 16 h / 20 °C

2: 96 percent / Et₃N / CH₂Cl₂ / 0.33 h / 20 °C

3: 40 percent / dimethylformamide / 4 h / 65 °C

4: 49 percent / aq. NaOH / methanol / 3.5 h / 20 °C

With sodium hydroxide; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.001