((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
CAS No.:1433280-18-2
Molecular Formula:C₂₁H₂₇BrN₄O₃S
Molecular Weight:495.44
Hs Code.:

Synonyms:((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Chemical Property of ((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Technology Process of ((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

There total 5 articles about ((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4-(4-bromo-phenyl)-2-((2S,4S)-4-methylsulfanyl-pyrrolidin-2-yl)-1H-imidazole di-hydrochloride

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1433280-18-2
((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: N-methoxycarbonyl-L-valine; With HATU; In N,N-dimethyl acetamide; for 0.166667h;

4-(4-bromo-phenyl)-2-((2S,4S)-4-methylsulfanyl-pyrrolidin-2-yl)-1H-imidazole di-hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃;

Reference yield:

: 1373164-85-2
(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1433280-18-2
((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h

2.1: HATU / N,N-dimethyl acetamide / 0.17 h

2.2: 20 °C

With hydrogenchloride; HATU; In 1,4-dioxane; N,N-dimethyl acetamide;

Reference yield:

: 188109-89-9
(2S,4S)-4-methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 1433280-18-2
((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methylsulfanyl-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 °C / Inert atmosphere

2.1: ammonium acetate / toluene / 100 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h

4.1: HATU / N,N-dimethyl acetamide / 0.17 h

4.2: 20 °C

With hydrogenchloride; ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; toluene;