2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

Base Information

Chemical Name:2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester
CAS No.:628314-66-9
Molecular Formula:C₄₄H₄₇N₃O₁₀
Molecular Weight:777.871
Hs Code.:

2-(2-<i>tert</i>-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

Synonyms:2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

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Chemical Property of 2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

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Technology Process of 2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

There total 3 articles about 2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 2-amino-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester; hydrochloride

: 628314-66-9
2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

Guidance literature:: N-tert-butoxycarbonyl-L-phenylalanine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.5h;

2-amino-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester; hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ol035673b

Reference yield:

: 123622-36-6
FMOC-Glu(OBn)-Cl

: 628314-66-9
2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuOK / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: HCl / H₂O; tetrahydrofuran / 1 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

3.2: 73 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium tert-butylate; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1021/ol035673b

Reference yield:

: 2-(benzhydrylidene-amino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

: 628314-66-9
2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / H₂O; tetrahydrofuran / 1 h / 20 °C

2.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

2.2: 73 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1021/ol035673b