FMOC-GLU(OBZL)-CL

Base Information

Chemical Name:FMOC-GLU(OBZL)-CL
CAS No.:123622-36-6
Molecular Formula:C27H24 Cl N O5
Molecular Weight:477.944
Hs Code.:
Mol file:123622-36-6.mol

Synonyms:Pentanoicacid, 5-chloro-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-oxo-, phenylmethylester, (S)-

Suppliers and Price of FMOC-GLU(OBZL)-CL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-γ-benzyl ester-L-glutamyl chloride
1g
$ 376.00

TRC
Fmoc-Glu(obzl)-Cl
10mg
$ 45.00

Chem-Impex
Fmoc-γ-benzylester-L-glutamylchloride,95% 95%
1G
$ 40.54

Chem-Impex
Fmoc-γ-benzyl ester-L-glutamyl chloride ≥ 95%
5G
$ 145.00

American Custom Chemicals Corporation
FMOC-GLU(OBZL)-CL 95.00%
1G
$ 637.00

American Custom Chemicals Corporation
FMOC-GLU(OBZL)-CL 95.00%
5MG
$ 500.28

AK Scientific
Fmoc-Glu(Obzl)-Cl
5g
$ 245.00

AK Scientific
Fmoc-Glu(Obzl)-Cl
1g
$ 98.00

Total 5 raw suppliers

Chemical Property of FMOC-GLU(OBZL)-CL

Chemical Property:

PSA：81.70000
LogP:5.57360
Storage Temp.:Store at 0°C

Purity/Quality:

≥ 95% ^*data from raw suppliers

Fmoc-γ-benzyl ester-L-glutamyl chloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Fmoc-Glu(obzl)-Cl is used as a reactant in the solid-phase synthesis of oxazole-containing peptidomimetics.

Technology Process of FMOC-GLU(OBZL)-CL

There total 1 articles about FMOC-GLU(OBZL)-CL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123639-61-2
Fmoc-L-glutamic acid-g-benzyl ester

: 123622-36-6
FMOC-Glu(OBn)-Cl

Guidance literature:: With thionyl chloride; In dichloromethane; for 0.5h; Yield given; Heating;
DOI:10.1021/jo00289a056

Reference yield:

: 123622-36-6
FMOC-Glu(OBn)-Cl

: 81167-39-7
methyl N-(diphenylmethylene)glycinate

: 2-(benzhydrylidene-amino)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-heptanedioic acid 7-benzyl ester 1-methyl ester

Guidance literature:: methyl N-(diphenylmethylene)glycinate; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.5h;

FMOC-Glu(OBn)-Cl; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/ol035673b

Reference yield:

: 123622-36-6
FMOC-Glu(OBn)-Cl

: methyl 2-{(1S)-2-phenyl-1-[(tert-butoxycarbonyl)amino]ethyl}-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(benzyloxycarbonyl)propyl}-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuOK / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: HCl / H₂O; tetrahydrofuran / 1 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

3.2: 73 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 °C

4.1: 71 percent / PPh₃; I₂; Et₃N / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium tert-butylate; iodine; triethylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol035673b