Technology Process of (+)-3-methyl-3-phenylhexanedioic acid
There total 5 articles about (+)-3-methyl-3-phenylhexanedioic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethylene glycol;
for 6h;
Heating;
DOI:10.1039/P19900002759
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / triethylamine / CH2Cl2 / 0.5 h
2: 88 percent / hexamethylphosphoric acid triamide; H2O / 24 h / 90 °C
3: 90 percent / KOH / ethane-1,2-diol / 6 h / Heating
With
potassium hydroxide; triethylamine;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; ethylene glycol;
DOI:10.1039/P19900002759
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / LiAlH4 / diethyl ether / 0 deg C, 24h, then reflux, 4h
2: 80 percent / triethylamine / CH2Cl2 / 0.5 h
3: 88 percent / hexamethylphosphoric acid triamide; H2O / 24 h / 90 °C
4: 90 percent / KOH / ethane-1,2-diol / 6 h / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; triethylamine;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; ethylene glycol;
DOI:10.1039/P19900002759
