Technology Process of (+)-2-methyl-2-phenylbutane-1,4-diol
There total 18 articles about (+)-2-methyl-2-phenylbutane-1,4-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R)-2-methyl-2-phenylbut-3-en-1-ol;
With
borane-THF;
In
tetrahydrofuran;
at 0 ℃;
for 5h;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran;
for 0.5h;
DOI:10.1002/chem.201903906
- Guidance literature:
-
(S)-(3-methylhexa-1,5-dien-3-yl)benzene;
With
ozone;
In
methanol; dichloromethane;
at -78 ℃;
for 0.0833333h;
With
sodium tetrahydroborate;
In
methanol; dichloromethane;
at 20 ℃;
optical yield given as %ee;
DOI:10.1002/anie.201008067
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane / 0.5 h / 0 °C
1.2: Inert atmosphere; Reflux
2.1: diisobutylaluminium hydride / dichloromethane / 0 °C / Inert atmosphere
3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere
4.1: tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride / tetrahydrofuran; water / 36 h / 60 °C / Inert atmosphere
5.1: ozone / methanol; dichloromethane / -78 °C
5.2: -78 - 20 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); n-butyllithium; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; tetra(n-butyl)ammonium hydrogensulfate; diisobutylaluminium hydride; ozone; cesium fluoride; sodium hydroxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1021/ja2039248
