(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

Base Information

Chemical Name:(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid
CAS No.:889853-44-5
Molecular Formula:C₁₈H₂₂ClN₃O₆
Molecular Weight:411.842
Hs Code.:

Synonyms:(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

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Chemical Property of (2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

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Technology Process of (2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

There total 17 articles about (2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoate

: 889853-44-5
(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 7.5h;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 889857-35-6
[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

: 889853-44-5
(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / methanol / 2 h / 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: 2 % platinum on carbon; hydrogen / tetrahydrofuran / 60 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

4.2: 0.33 h / -78 °C

5.1: triethylamine / N,N-dimethyl-formamide / 3 h / 0 °C

6.1: trifluoroacetic acid / dichloromethane / 7.5 h / 0 - 20 °C

With n-butyllithium; 2 % platinum on carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 889857-36-7
C₂₃H₂₇ClN₂O₇*ClH

: 889853-44-5
(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: 2 % platinum on carbon; hydrogen / tetrahydrofuran / 60 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

3.2: 0.33 h / -78 °C

4.1: triethylamine / N,N-dimethyl-formamide / 3 h / 0 °C

5.1: trifluoroacetic acid / dichloromethane / 7.5 h / 0 - 20 °C

With n-butyllithium; 2 % platinum on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.079