[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

Base Information

• Chemical Name: [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride
• CAS No.: 889857-35-6
• Molecular Formula: C₂₅H₃₁ClN₂O₇*ClH
• Molecular Weight: 543.444
• Mol file: 889857-35-6.mol

Synonyms:[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

Chemical Property of [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

There total 10 articles about [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H29ClN2O7*ClH → [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride (889857-35-6)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2013.04.079

Reference yield:

5-chloro-2-methoxybenzaldehyde (7035-09-8) → [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride (889857-35-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; lanthanum(lll) triflate; 2,2'-iminobis[ethanol] / 60 h / 20 °C

2: triethylamine; pyridine / dichloromethane / 1 h / 0 °C

3: sodium azide / dimethyl sulfoxide / 0.5 h / 20 °C

4: triphenylphosphine / tetrahydrofuran; water / 15 h / 20 °C

5: sodium hydroxide; water / methanol / 2 h / 20 °C

6: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Cooling with ice

8: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

9: tetrahydrofuran / 0.33 h / 20 °C

10: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium azide; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,2'-iminobis[ethanol]; triphenylphosphine; sodium hydroxide; lanthanum(lll) triflate; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; 1: |Baylis-Hillman Reaction;

DOI:10.1016/j.bmc.2013.04.079

Reference yield:

methyl 2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]propenoate (889855-37-2) → [((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride (889857-35-6)

Guidance literature:

Multi-step reaction with 9 steps

1: triethylamine; pyridine / dichloromethane / 1 h / 0 °C

2: sodium azide / dimethyl sulfoxide / 0.5 h / 20 °C

3: triphenylphosphine / tetrahydrofuran; water / 15 h / 20 °C

4: sodium hydroxide; water / methanol / 2 h / 20 °C

5: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Cooling with ice

7: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

8: tetrahydrofuran / 0.33 h / 20 °C

9: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 °C

With pyridine; hydrogenchloride; sodium azide; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.bmc.2013.04.079

upstream raw materials:

5-chloro-2-methoxybenzaldehyde

methyl 2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]propenoate

methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate

methyl (2E)-2-(azidomethyl)-3-(5-chloro-2-methoxyphenyl)-2-propenoate

Downstream raw materials:

6-(5-chloro-2-methoxybenzyl)-N-{(1R)-1-[(methylamino)carbonyl]propyl}-3,7-dioxo-1,4-diazepan-1-carboxamide

{[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetic acid

(2S)-2-{[(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}propanoic acid

(2R)-2-{[(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl] amino}propanoic acid