2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester
CAS No.:916049-73-5
Molecular Formula:C₃₆H₄₈N₂O₈Si
Molecular Weight:664.871
Hs Code.:

2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

Synonyms:2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

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Chemical Property of 2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

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Technology Process of 2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

There total 5 articles about 2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17715-69-4
1-Bromo-2,4-dimethoxybenzene

: 916049-73-5
2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 92 percent / tetrahydrofuran / 2 h / 20 °C

2.1: 91 percent / potassium iodide; potassium carbonate / dimethylformamide / 12 h / 90 °C

3.1: 1.04 g / CH₂Cl₂ / 12 h / 20 °C

With n-butyllithium; potassium carbonate; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja064737l

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 916049-73-5
2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.42 h / -15 °C

2: 1.04 g / CH₂Cl₂ / 12 h / 20 °C

With 4-methyl-morpholine; In dichloromethane;
DOI:10.1021/ja064737l

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 916049-73-5
2-((3-benzyloxy-2-tert-butoxycarbonylaminopropionyl){[(2,4-dimethoxyphenyl)dimethylphenylsilanyl]methyl}amino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / potassium iodide; potassium carbonate / dimethylformamide / 12 h / 90 °C

2: 1.04 g / CH₂Cl₂ / 12 h / 20 °C

With potassium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja064737l