Technology Process of 18-methoxy-4-methoxymethoxy-2-oxa-tricyclo[13.3.1.13,7]icosa-1(18),3(20),4,6,15(19),16-hexaen-10-one
There total 1 articles about 18-methoxy-4-methoxymethoxy-2-oxa-tricyclo[13.3.1.13,7]icosa-1(18),3(20),4,6,15(19),16-hexaen-10-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: bromine / dichloromethane / 0 °C
2.1: potassium carbonate / acetone / 0 °C
3.1: water; lithium hydroxide / tetrahydrofuran
4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran
4.2: 20 °C
5.1: tetrahydrofuran; diethyl ether / 4 h / 20 °C
6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 2 h / Reflux
7.1: palladium on activated charcoal; hydrogen / dichloromethane / 4 h / 20 °C
8.1: potassium carbonate; copper(II) oxide / pyridine / 30 h / 200 °C
With
4-methyl-morpholine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; palladium on activated charcoal; water; hydrogen; bromine; potassium carbonate; copper(II) oxide; lithium hydroxide;
In
tetrahydrofuran; pyridine; diethyl ether; dichloromethane; acetone; toluene;
8.1: Ullmann reaction;
DOI:10.1016/j.bmcl.2011.11.025
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / methanol / 20 °C
2: potassium carbonate / acetone / 6 h / Reflux
With
hydrogenchloride; potassium carbonate;
In
methanol; acetone;
DOI:10.1038/ja.2013.21
