N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

Base Information

Chemical Name:N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester
CAS No.:96866-06-7
Molecular Formula:C₂₆H₂₆N₂O₅
Molecular Weight:446.503
Hs Code.:

Synonyms:N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

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Chemical Property of N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

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Technology Process of N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

There total 5 articles about N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: 67681-99-6
α-[(benzyloxy)carbamoyl]hydrocinnamic acid

: 96866-06-7
N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00147a007

Reference yield:

: 2985-39-9,175521-78-5
2-benzylmalonic acid monoethyl ester

: 96866-06-7
N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 64 percent / 2.5 N aq. NaOH / methanol / 4 h / Ambient temperature

3: 75 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), N-cyclohexyl-N'-<2-(4-morpholinyl)ethyl>carbodiimide methol p-toluenosulfonate / tetrahydrofuran / Ambient temperature

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00147a007

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 96866-06-7
N-<2(RS)-<<(benzyloxy)amino>carbonyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 64 percent / 2.5 N aq. NaOH / methanol / 4 h / Ambient temperature

3: 75 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), N-cyclohexyl-N'-<2-(4-morpholinyl)ethyl>carbodiimide methol p-toluenosulfonate / tetrahydrofuran / Ambient temperature

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00147a007