Technology Process of cyanoalcohol
There total 3 articles about cyanoalcohol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; n-butyllithium; Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol);
In
tetrahydrofuran; ethanol; hexane;
at -78 - 0 ℃;
for 4h;
warming to room temperature over 1 h;
DOI:10.1080/00397919808004439
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / piperidine; benzoic acid / benzene / refluxing overnight under an argon atmosphere with Dean-Stark trap
2: 70 percent / ethanol; H2O / 70 °C / stirring overnight at 70 deg C
3: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h
With
sodium tetrahydroborate; n-butyllithium; Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol);
piperidine; benzoic acid;
In
tetrahydrofuran; ethanol; hexane; water; benzene;
1: Condensation / 2: Cyanidation / 3: Reduction;
DOI:10.1080/00397919808004439
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 70 percent / ethanol; H2O / 70 °C / stirring overnight at 70 deg C
2: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h
With
sodium tetrahydroborate; n-butyllithium; Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol);
In
tetrahydrofuran; ethanol; hexane; water;
1: Cyanidation / 2: Reduction;
DOI:10.1080/00397919808004439
