Carbamic acid, (3-hydroxycyclopentyl)-, 1,1-dimethylethyl ester, (1S-trans)-

Base Information

• Chemical Name: Carbamic acid, (3-hydroxycyclopentyl)-, 1,1-dimethylethyl ester, (1S-trans)-
• CAS No.: 154737-89-0
• Molecular Formula: C10H19 N O3
• Molecular Weight: 201.266
• Mol file: 154737-89-0.mol

Synonyms:Carbamic acid, (3-hydroxycyclopentyl)-, 1,1-dimethylethyl ester, (1S-trans)-

Chemical Property of Carbamic acid, (3-hydroxycyclopentyl)-, 1,1-dimethylethyl ester, (1S-trans)-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 320.8°Cat760mmHg
• PKA: 12.27±0.40(Predicted)
• Flash Point: 147.8°C
• PSA: 58.56000
• Density: 1.08g/cm³
• LogP: 1.81540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-butylN-[(1S,3S)-3-hydroxycyclopentyl]carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (3-hydroxycyclopentyl)-, 1,1-dimethylethyl ester, (1S-trans)-

There total 5 articles about Carbamic acid, (3-hydroxycyclopentyl)-, 1,1-dimethylethyl ester, (1S-trans)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1S,3S)-3-(tert-butoxycarbonylamino)cyclopentyl 4-nitrobenzoate → tert-butyl ((1S,3S)-3-hydroxycyclopentyl)carbamate (154737-89-0,1154870-59-3,207729-04-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h;

Reference yield: 44.0%

tert-butyl N-(3-oxocyclopentyl)carbamate (847416-99-3) → tert-butyl ((1S,3S)-3-hydroxycyclopentyl)carbamate (154737-89-0,1154870-59-3,207729-04-2) + (+/-)-tert-butyl (cis-3-hydroxycyclopentyl)carbamate (1154870-59-3,207729-04-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2.5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl ((1S,3S)-3-hydroxycyclopentyl)carbamate (154737-89-0,1154870-59-3,207729-04-2) + (+/-)-tert-butyl (cis-3-hydroxycyclopentyl)carbamate (1154870-59-3,207729-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h

2: sodium tetrahydroborate / ethanol / 2.5 h / 0 °C

With sodium tetrahydroborate; hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate;

upstream raw materials:

tert-butyl N-(3-oxocyclopentyl)carbamate

(1S,3R)-3-hydroxycyclopentyl-1-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

(1S,3S)-3-aminocyclopentan-1-ol

[(1S,3S)-3-(2-Amino-5-fluoro-phenoxy)-cyclopentyl]-carbamic acid tert-butyl ester

[(1S,3S)-3-(5-fluoro-2-nitro-phenoxy)-cyclopentyl]-methyl-carbamic acid tert-butyl ester

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