847416-99-3Relevant academic research and scientific papers
Decarboxylative Oxygenation via Photoredox Catalysis
Faraggi, Tomer M.,Li, Wei,MacMillan, David W. C.
, p. 410 - 415 (2019/12/24)
The direct conversion of aliphatic carboxylic acids to their dehomologated carbonyl analogues has been accomplished through photocatalytic decarboxylative oxygenation. This transformation is applicable to an array of carboxylic acid motifs, producing ketones, aldehydes, and amides in excellent yields. Preliminary results demonstrate that this methodology is further amenable to aldehyde substrates via in situ oxidation to the corresponding acid and subsequent decarboxylative oxygenation. We have exploited this strategy for the sequential oxidative dehomologation of linear aliphatic chains.
SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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, (2016/05/02)
Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
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, (2016/08/17)
The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY
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Page/Page column 51, (2016/07/05)
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.
TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
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, (2015/04/15)
The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein n, X, Y, Z, R1, R2, and R3 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
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Paragraph 000136, (2015/03/13)
The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.
Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
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, (2015/06/17)
The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
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, (2014/02/15)
The invention provides novel compounds having the general formula: formula (I) wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
HETEROARYL SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS
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Paragraph 00280, (2019/03/15)
Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.
Synthesis of 5-(3,4-dichlorophenyl)-4-[(methyloxy)methyl]-2-azabicyclo[3.2. 1]octane derivatives as constrained aryl-piperidines with activity as triple re-uptake inhibitors
Profeta, Roberto,Klein, Jens,Spada, Simone,Ferroni, Francesco,Paio, Alfredo,Andreotti, Daniele
scheme or table, p. 5521 - 5524 (2010/11/03)
Stereochemical and synthetic aspects encountered during the preparation of the four possible isomers of 1 are reported. The 5-aryl 2-azabicyclo [3.2.1] octane derivatives represent a novel class of compounds which can be deemed as an example of aryl-piperidine conformationally constrained of potential interest for medicinal chemistry exploration. In particular isomers of 1 are characterised by a potent in vitro serotonine, dopamine and noradrenaline re-uptake inhibitor (TRUI) activity superior/comparable to standard compounds such as DOV 21,947 and DOV 102,677.
