1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

Base Information

Chemical Name:1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate
CAS No.:478316-38-0
Molecular Formula:C₂₇H₂₂INO₄S
Molecular Weight:583.446
Hs Code.:

Synonyms:1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

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Chemical Property of 1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

Chemical Property:

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Technology Process of 1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

There total 8 articles about 1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 478316-30-2
1-[2-(2-iodophenyl)-2-oxo-ethyl]naphthalen-2-yl benzenesulfonate

: 478316-38-0
1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

Guidance literature:: In toluene; at 90 ℃;
DOI:10.1021/jo025767j

Reference yield:

: 26260-02-6
2-iodobenzaldehyde

: 478316-38-0
1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / H₂O; acetonitrile / 20 °C

2.1: NaH / dimethylformamide / -19 °C

2.2: dimethylformamide / -19 - 20 °C

3.1: 51 percent / conc. HCl / methanol; H₂O / 90 °C

4.1: 45 percent / toluene / 90 °C

With hydrogenchloride; sodium hydride; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 478316-38-0
1-[2-(N,N-dimethylamino)-1-(2-iodobenzoyl)vinyl]naphthalen-2-yl benzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 87 percent / pyridine / 80 °C

2.1: 85 percent / LAH / tetrahydrofuran / -19 °C

3.1: CBr₄ / CH₂Cl₂ / 20 °C

3.2: 62 percent / PPh₃ / CH₂Cl₂ / 0 °C

4.1: NaH / dimethylformamide / -19 °C

4.2: dimethylformamide / -19 - 20 °C

5.1: 51 percent / conc. HCl / methanol; H₂O / 90 °C

6.1: 45 percent / toluene / 90 °C

With hydrogenchloride; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j