tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate

Base Information

• Chemical Name: tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate
• CAS No.: 1018690-31-7
• Molecular Formula: C₂₂H₂₅F₂N₃O₃S
• Molecular Weight: 449.522
• Mol file: 1018690-31-7.mol

Synonyms:tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate

Chemical Property of tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate

There total 4 articles about tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-difluoro-benzothiohydrazide (885060-36-6) + tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate (1018690-30-6) → tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate (1018690-31-7)

Guidance literature:

In ethanol; for 30h;

Reference yield:

C7H4F2S2 (1021853-64-4) → tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate (1018690-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water / 14 h / 20 °C

2: sodium hydroxide; hydrazine / 14 h / 0 - 20 °C

3: ethanol / 30 h

With sodium hydroxide; sodium hydrogencarbonate; hydrazine; In ethanol; water;

Reference yield:

2-(2,5-difluoro-phenylcarbonothioylthio)acetic acid (1018690-18-0) → tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate (1018690-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; hydrazine / 14 h / 0 - 20 °C

2: ethanol / 30 h

With sodium hydroxide; hydrazine; In ethanol;

upstream raw materials:

2,5-difluoro-benzothiohydrazide

tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate

C₇H₄F₂S₂

2-(2,5-difluoro-phenylcarbonothioylthio)acetic acid

Downstream raw materials:

C₂₆H₃₁F₂N₃O₅S