tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate

Base Information

• Chemical Name: tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate
• CAS No.: 1018690-30-6
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 1018690-30-6.mol

Synonyms:tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate

Chemical Property of tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate

There total 2 articles about tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-chloropropiophenone (936-59-4) + N-(tert-butoxycarbonyl)-O-methylhydroxylamine (58377-44-9) → tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate (1018690-30-6)

Guidance literature:

N-(tert-butoxycarbonyl)-O-methylhydroxylamine; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.583333h;

3-chloropropiophenone; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate (1018690-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / dichloromethane; water / 18 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

2.2: 0.5 h / 20 °C

With sodium hydride; sodium carbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

2,5-difluoro-benzothiohydrazide (885060-36-6) + tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate (1018690-30-6) → tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate (1018690-31-7)

Guidance literature:

In ethanol; for 30h;

upstream raw materials:

3-chloropropiophenone

N-(tert-butoxycarbonyl)-O-methylhydroxylamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl(methoxy)carbamate

C₂₆H₃₁F₂N₃O₅S