N¹,N⁷-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine

Base Information

• Chemical Name: N¹,N⁷-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine
• CAS No.: 258337-57-4
• Molecular Formula: C₅₄H₅₈N₉O₉P₃
• Molecular Weight: 1070.03

Synonyms:N¹,N⁷-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine

Chemical Property of N¹,N⁷-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine

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Technology Process of N¹,N⁷-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine

There total 4 articles about N¹,N⁷-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-nitro-1H-imidazole (527-73-1) + N1,N7-Bis(2',3'-epoxypropyl)-N1,N4,N7-tris(diphenylphosphinoyl)norspermidine (258337-56-3) → N1,N7-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N1,N4,N7-tris(diphenylphosphinoyl)norspermidine (258337-57-4)

Guidance literature:

With triethylamine; In methanol; at 120 ℃; for 5h;

DOI:10.1039/a903293b

Reference yield:

bis(3-aminopropyl)amine (56-18-8) → N1,N7-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N1,N4,N7-tris(diphenylphosphinoyl)norspermidine (258337-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / NEt₃ / tetrahydrofuran / 1 h

2: 69 percent / NaH / tetrahydrofuran / 6 h / 90 °C

3: 81 percent / NEt₃ / methanol / 5 h / 120 °C

With sodium hydride; triethylamine; In tetrahydrofuran; methanol; 1: Phosphinylation / 2: Ring cleavage / 3: Ring cleavage;

DOI:10.1039/a903293b

Reference yield:

N1,N4,N7-Tris(diphenylphosphinoyl)norspermidine (258337-55-2) → N1,N7-Bis[2''-hydroxy-3''-(2'-nitroimidazol-1'-yl)propyl]-N1,N4,N7-tris(diphenylphosphinoyl)norspermidine (258337-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / NaH / tetrahydrofuran / 6 h / 90 °C

2: 81 percent / NEt₃ / methanol / 5 h / 120 °C

With sodium hydride; triethylamine; In tetrahydrofuran; methanol; 1: Ring cleavage / 2: Ring cleavage;

DOI:10.1039/a903293b

upstream raw materials:

2-nitro-1H-imidazole

N¹,N⁷-Bis(2',3'-epoxypropyl)-N¹,N⁴,N⁷-tris(diphenylphosphinoyl)norspermidine

bis(3-aminopropyl)amine

N¹,N⁴,N⁷-Tris(diphenylphosphinoyl)norspermidine

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