1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Base Information

Chemical Name:1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene
CAS No.:1344700-45-3
Molecular Formula:C₂₅H₂₇N₃O₄
Molecular Weight:433.507
Hs Code.:

Synonyms:1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

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Chemical Property of 1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

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Technology Process of 1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

There total 14 articles about 1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1344700-44-2
1-formyl-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

: 765-30-0
Cyclopropylamine

: 1344700-45-3
1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Guidance literature:: 1-formyl-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene; Cyclopropylamine; With acetic acid; In chloroform; at 20 ℃; for 2.5h;

With sodium tris(acetoxy)borohydride; In chloroform; at 20 ℃; for 15h;

Reference yield:

: 1344700-26-0
4-[2-(4-formylphenyl)ethynyl]benzoic acid ethyl ester

: 1344700-45-3
1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 10-camphorsufonic acid / 3 h / 20 °C

2.1: water; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: hydrogenchloride / acetone / 15 h / 20 °C / Cooling with ice

5.1: acetic acid / chloroform / 2.5 h / 20 °C

5.2: 15 h / 20 °C

With hydrogenchloride; 10-camphorsufonic acid; water; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1344700-41-9
ethyl 4-{[4-(dimethoxymethyl)phenyl]ethynyl}benzoate

: 1344700-45-3
1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: hydrogenchloride / acetone / 15 h / 20 °C / Cooling with ice

4.1: acetic acid / chloroform / 2.5 h / 20 °C

4.2: 15 h / 20 °C

With hydrogenchloride; water; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetone;