(Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide

Base Information

• Chemical Name: (Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide
• CAS No.: 1560811-67-7
• Molecular Formula: C₂₄H₂₄F₃NO₂S
• Molecular Weight: 447.521
• Mol file: 1560811-67-7.mol

Synonyms:(Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide

Chemical Property of (Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide

There total 1 articles about (Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + (Rs)-2-methyl-N-((S)-1-(2-(phenylethynyl)-5-(trifluoromethyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide (1560811-30-4) → (Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide (1560811-67-7) + C24H24F3NO2S (1560811-70-2)

Guidance literature:

dicobalt octacarbonyl; (Rs)-2-methyl-N-((S)-1-(2-(phenylethynyl)-5-(trifluoromethyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 12h; Overall yield = 80 %; Inert atmosphere;

DOI:10.1021/ol500142c

Reference yield: 95.0%

(Rs)-2-methyl-N-((3aR,5S)-2-oxo-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-5-yl)propane-2-sulfinamide (1560811-67-7) → (3aR,5S)-5-amino-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-2-one hydrochloride (1560810-94-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃; for 0.75h; Inert atmosphere;

DOI:10.1021/ol500142c

upstream raw materials:

dicobalt octacarbonyl

(Rs)-2-methyl-N-((S)-1-(2-(phenylethynyl)-5-(trifluoromethyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide

Downstream raw materials:

(3aR,5S)-5-amino-1-phenyl-7-(trifluoromethyl)-3,3a,4,5-tetrahydro-2H-cyclopenta[a]naphthalen-2-one hydrochloride