3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

Base Information

• Chemical Name: 3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline
• CAS No.: 1373417-07-2
• Molecular Formula: C₁₇H₂₆F₂N₄O
• Molecular Weight: 340.416
• Mol file: 1373417-07-2.mol

Synonyms:3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

Chemical Property of 3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

Chemical Property:

• Boiling Point: 484.7±45.0 °C(Predicted)
• Density: 1.209±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

There total 2 articles about 3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{1-[2-(difluoromethoxy)-4-nitrophenyl]piperidin-4-yl}-4-methylpiperazine (1373417-03-8) → 3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1373417-07-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 1h; Inert atmosphere;

Reference yield:

1-chloro-2-(difluoromethoxy)-4-nitrobenzene (40319-62-8) + 1-methyl-4-(piperidin-4-yl)piperazine (53617-36-0) → 3-(difluoromethoxy)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1373417-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

1-chloro-2-(difluoromethoxy)-4-nitrobenzene

1-methyl-4-(piperidin-4-yl)piperazine

1-{1-[2-(difluoromethoxy)-4-nitrophenyl]piperidin-4-yl}-4-methylpiperazine