7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Base Information

• Chemical Name: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine
• CAS No.: 442907-10-0
• Molecular Formula: C₉H₈N₆O
• Molecular Weight: 216.202
• Mol file: 442907-10-0.mol

Synonyms:7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Chemical Property of 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

There total 3 articles about 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-(5-methyl-2-furyl)pyrimidine-2,4,5-triamine (442910-18-1) → 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (442907-10-0)

Guidance literature:

With isopentyl nitrite; In 1,4-dioxane; at 80 ℃; for 3.5h;

DOI:10.1021/jm800961g

Reference yield:

5-methylfuran-2-boronic acid (62306-79-0) → 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (442907-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 40 °C

3: isopentyl nitrite / 1,4-dioxane / 3.5 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Suzuki coupling;

DOI:10.1021/jm800961g

Reference yield:

C9H9N5O3 (442910-17-0) → 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (442907-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 40 °C

2: isopentyl nitrite / 1,4-dioxane / 3.5 h / 80 °C

With palladium 10% on activated carbon; hydrogen; isopentyl nitrite; In 1,4-dioxane; methanol;

DOI:10.1021/jm800961g

upstream raw materials:

6-(5-methyl-2-furyl)pyrimidine-2,4,5-triamine

5-methylfuran-2-boronic acid

C₉H₉N₅O₃

Downstream raw materials:

3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine