3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Base Information

Chemical Name:3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine
CAS No.:442907-12-2
Molecular Formula:C₁₆H₁₃FN₆O
Molecular Weight:324.317
Hs Code.:

Synonyms:3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

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Chemical Property of 3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

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Technology Process of 3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

There total 4 articles about 3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 446-48-0
o-fluorobenzyl bromide

: 442907-10-0
7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

: 442907-12-2
3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Guidance literature:: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

o-fluorobenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm800961g

Reference yield:

: 442910-18-1
6-(5-methyl-2-furyl)pyrimidine-2,4,5-triamine

: 442907-12-2
3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopentyl nitrite / 1,4-dioxane / 3.5 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 1 h / 20 °C

With sodium hydride; isopentyl nitrite; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm800961g

Reference yield:

: 442910-17-0
C₉H₉N₅O₃

: 442907-12-2
3-(2-fluorobenzyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 40 °C

2.1: isopentyl nitrite / 1,4-dioxane / 3.5 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; isopentyl nitrite; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm800961g