6-Chloroimidazo[1,2-B]pyridazine-3-carbaldehyde

Base Information

• Chemical Name: 6-Chloroimidazo[1,2-B]pyridazine-3-carbaldehyde
• CAS No.: 154578-26-4
• Molecular Formula: C₇H₄ClN₃O
• Molecular Weight: 181.581
• Hs Code.: 2933990090
• European Community (EC) Number: 848-344-8
• DSSTox Substance ID: DTXSID50466091
• Wikidata: Q82292530
• Mol file: 154578-26-4.mol

Synonyms:6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-3-CARBALDEHYDE;154578-26-4;6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXALDEHYDE;MFCD11044762;6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-carbaldehyde;IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXALDEHYDE, 6-CHLORO-;SCHEMBL1163131;DTXSID50466091;WYUDQEUQUMBLRF-UHFFFAOYSA-N;AMY23896;AKOS006309726;CS-W003755;PB17781;DS-16602;SY004910;FT-0744180;EN300-117365;6-chloroimidazo[1,2-b]pyridazine-3-carboxaldehyde;6-Chloroimidazo[1 pound not2-b]pyridazine-3-carbaldehyde

Chemical Property of 6-Chloroimidazo[1,2-B]pyridazine-3-carbaldehyde

Chemical Property:

• Refractive Index: 1.716
• PKA: 1.03±0.30(Predicted)
• PSA: 47.26000
• Density: 1.579g/cm3
• LogP: 1.19520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 181.0042895
• Heavy Atom Count: 12
• Complexity: 190

Purity/Quality:

97% ^*data from raw suppliers

6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN2C1=NC=C2C=O)Cl

Technology Process of 6-Chloroimidazo[1,2-B]pyridazine-3-carbaldehyde

There total 3 articles about 6-Chloroimidazo[1,2-B]pyridazine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(6-chloro-pyridazin-3-ylamino)-propane-1,2-diol → 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde (154578-26-4)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/S0040-4039(03)00426-X

Reference yield: 54.0%

(6-chloroimidazo[1,2-b]pyridazin-3-yl)methanol (675580-49-1) → 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde (154578-26-4)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

Reference yield:

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde (154578-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium acetate; acetic acid / Reflux

1.2: pH 12

2.1: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; sodium acetate; acetic acid; In dichloromethane;

upstream raw materials:

6-chloroimidazo[1,2-b]pyridazine

(6-chloroimidazo[1,2-b]pyridazin-3-yl)methanol

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