2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158

Base Information

• Chemical Name: 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158
• CAS No.: 154554-41-3
• Molecular Formula: C16H10 F N O3
• Molecular Weight: 283.259
• Mol file: 154554-41-3.mol

Synonyms:CHM 1; NSC656158

Chemical Property of 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥5mg/mL

Purity/Quality:

97% ^*data from raw suppliers

CHM 1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: CHM-1 is a potent apoptosis inducer.

Technology Process of 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158

There total 9 articles about 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-(6-bromobenzo[d][1,3]dioxol-5-yl)-3-(2-fluorophenyl)prop-2-yn-1-one → CHM-1 (154554-41-3)

Guidance literature:

With copper(l) iodide; ammonium carbonate; In formamide; at 100 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.0c00172

Reference yield: 73.0%

→ CHM-1 (154554-41-3)

Guidance literature:

With copper(l) iodide; ammonium carbonate; formamide; at 100 ℃; for 12h; Sealed tube;

Reference yield:

N-(6-Acetyl-benzo[1,3]dioxol-5-yl)-2-fluoro-benzamide (666818-14-0) → CHM-1 (154554-41-3)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 70 ℃; Yield given;

DOI:10.1021/jm00034a010

upstream raw materials:

N-(6-Acetyl-benzo[1,3]dioxol-5-yl)-2-fluoro-benzamide

2-amino-4,5-methylenedioxy-acetophenone

2-Fluorobenzoyl chloride

6-bromo-3,4-methylenedioxybenzaldehyde

Downstream raw materials:

4-[6-(2-fluoro-phenyl)-[1,3]dioxolo[4,5-g]quinolin-8-yloxy]-butyric acid ethyl ester

dibenzyl 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-yl phosphate

8-chloro-6-(2-fluorophenyl)-[1,3]-dioxolo[4,5-g]quinoline

6-(2-fluorophenyl)-[1,3]dioxolo[4,5-g]quinolin-8-yl 3,4,5-trimethoxybenzenesulfonate