(S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate

Base Information

• Chemical Name: (S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate
• CAS No.: 869542-56-3
• Molecular Formula: C₁₆H₂₀O₄
• Molecular Weight: 276.332
• Mol file: 869542-56-3.mol

Synonyms:(S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate

Chemical Property of (S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate

There total 1 articles about (S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenylglyoxylic acid ethyl ester (1603-79-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate (869542-56-3)

Guidance literature:

With L-proline; In dimethyl sulfoxide; at 20 ℃; for 72h;

DOI:10.1021/ol052164w

Reference yield:

(S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate (869542-56-3) → (S)-Hydroxy-(2-hydroxy-cyclohexyl)-phenyl-acetic acid ethyl ester

Guidance literature:

(S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 2h;

In methanol; at 20 ℃; for 12h;

DOI:10.1021/ol052164w

Reference yield:

(S)-ethyl 2-(2-oxocyclohexyl)-2-phenylglycolate (869542-56-3) → (S)-ethyl 2-(cyclohex-2-enyl)-2-phenylglycolate (869542-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BH₃*Me₂S / tetrahydrofuran / 2 h / 20 °C

1.2: methanol / 12 h / 20 °C

2.1: 1.52 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: LiCl; HMPA / 4 h / 80 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dimethylsulfide borane complex; triethylamine; lithium chloride; In tetrahydrofuran;

DOI:10.1021/ol052164w

upstream raw materials:

phenylglyoxylic acid ethyl ester

cyclohexanone

Downstream raw materials:

(S)-ethyl 2-(cyclohex-2-enyl)-2-phenylglycolate

(S)-ethyl 2-cyclohexyl-2-phenylglycolate

(S)-ethyl 2-(cyclohex-1-enyl)-2-phenylglycolate

(S)-ethyl 2-(2-methanesulfonyloxycyclohexyl)-2-phenylglycolate