(R)-N-Benzyloxycarbonyl-2-piperidinemethanol

Base Information

• Chemical Name: (R)-N-Benzyloxycarbonyl-2-piperidinemethanol
• CAS No.: 154499-13-5
• Molecular Formula: C14H19 N O3
• Molecular Weight: 249.31
• DSSTox Substance ID: DTXSID30456273
• Wikidata: Q82278612
• Mol file: 154499-13-5.mol

Synonyms:(R)-N-Benzyloxycarbonyl-2-piperidinemethanol;154499-13-5;benzyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate;(R)-Benzyl 2-(hydroxymethyl)piperidine-1-carboxylate;SCHEMBL80752;DTXSID30456273;UDGDHNGWPNSYCD-CYBMUJFWSA-N;AB6213;AKOS025405236;CS-0324291;EN300-383238;A1-35800;Benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property of (R)-N-Benzyloxycarbonyl-2-piperidinemethanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 396.374°C at 760 mmHg
• Flash Point: 193.52°C
• PSA: 49.77000
• Density: 1.163g/cm³
• LogP: 2.10790
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 249.13649347
• Heavy Atom Count: 18
• Complexity: 264

Purity/Quality:

98%min ^*data from raw suppliers

(R)-N-Benzyloxycarbonyl-2-piperidinemethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C(C1)CO)C(=O)OCC2=CC=CC=C2
• Isomeric SMILES: C1CCN([C@H](C1)CO)C(=O)OCC2=CC=CC=C2
• Uses: Intermediate for the preparation of 1-hydroxyalkyl-3-phenylthioureas as HDL- and Apo A-I-elevating agents

Technology Process of (R)-N-Benzyloxycarbonyl-2-piperidinemethanol

There total 7 articles about (R)-N-Benzyloxycarbonyl-2-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid (28697-07-6,28697-09-8,28697-11-2,71170-88-2) → benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate (154499-13-5)

Guidance literature:

With diborane;

DOI:10.1016/j.bmcl.2004.10.094

Reference yield: 48.0%

→ benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate (154499-13-5)

Guidance literature:

Reference yield: 37.0%

vinyl n-butyrate (123-20-6,24991-31-9) + 1-benzyloxycarbonyl-2-hydroxymethylpiperidine (105706-75-0) → (S)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester (212557-00-1) + benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate (154499-13-5) + (S)-2-Butyryloxymethyl-piperidine-1-carboxylic acid benzyl ester

Guidance literature:

vinyl n-butyrate; 1-benzyloxycarbonyl-2-hydroxymethylpiperidine; With acylase I from Aspergillus species; In toluene; at 20 ℃; for 6h; Enzymatic reaction;

With phosphate buffer; acylase I from Aspergillus species; In water; at 20 ℃; for 7h; pH=7.0; Enzymatic reaction;

upstream raw materials:

(R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid

vinyl n-butyrate

1-benzyloxycarbonyl-2-hydroxymethylpiperidine

benzyl chloroformate

Downstream raw materials:

(2R)-piperidin-2-ylmethanol

[(2R)-1-[(benzyloxy)carbonyl]piperidin-2-yl]methyl 4-methylpiperazine-1-carboxylate

C₁₇H₂₃NO₆

C₁₇H₂₃NO₆

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 154499-13-5 (+)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send